Synthesis and antibacterial activities of novel C(7)-catechol-substituted cephalosporins (I).

Cephalosporins have been widely used for treating diseases caused by pathogenic bacteria in human and animals. Through the tonB dependent iron transport mechanism,1>2) the use of catechol substituted /Mactams was knownto increase the drug's penetration into the bacterial cell walls. Thus, several catechol-substituted /Mactams have been synthesized and showed good antipseudomonal activities.3 ~ 8) Despite their excellent antipseudomonal activities compared with those of other cephalosporins, most of the catechol substituted cephalosporins have weak activity against Gram-positive bacteria.3~7) Also, there has been emerging resistance